Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia.
Identifieur interne : 001210 ( Main/Exploration ); précédent : 001209; suivant : 001211Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia.
Auteurs : Hien Duong Liu [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Zhen-Huan Hu [États-Unis] ; Mehdi Hamadani [États-Unis] ; Taiga Nishihori [États-Unis] ; Baldeep Wirk [États-Unis] ; Amer Beitinjaneh [États-Unis] ; David Rizzieri [États-Unis] ; Michael R. Grunwald [États-Unis] ; Mitchell Sabloff [Canada] ; Richard F. Olsson [Suède] ; Ashish Bajel [Australie] ; Christopher Bredeson [Canada] ; Andrew Daly [Canada] ; Yoshihiro Inamoto [Japon] ; Navneet Majhail [États-Unis] ; Ayman Saad [États-Unis] ; Vikas Gupta [Canada] ; Aaron Gerds [États-Unis] ; Adriana Malone [États-Unis] ; Martin Tallman [États-Unis] ; Ran Reshef [États-Unis] ; David I. Marks [Royaume-Uni] ; Edward Copelan [États-Unis] ; Usama Gergis [États-Unis] ; Mary Lynn Savoie [Canada] ; Celalettin Ustun [États-Unis] ; Mark R. Litzow [États-Unis] ; Jean-Yves Cahn [France] ; Tamila Kindwall-Keller [États-Unis] ; Gorgun Akpek [États-Unis] ; Bipin N. Savani [États-Unis] ; Mahmoud Aljurf [Arabie saoudite] ; Jacob M. Rowe [Israël] ; Peter H. Wiernik [États-Unis] ; Jack W. Hsu [États-Unis] ; Jorge Cortes [États-Unis] ; Matt Kalaycio [États-Unis] ; Richard Maziarz [États-Unis] ; Ronald Sobecks [États-Unis] ; Uday Popat [États-Unis] ; Edwin Alyea [États-Unis] ; Wael Saber [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2017.
Abstract
Allogeneic hematopoietic cell transplantation (HCT) is potentially curative for patients with chronic myelomonocytic leukemia (CMML); however, few data exist regarding prognostic factors and transplantation outcomes. We performed this retrospective study to identify prognostic factors for post-transplantation outcomes. The CMML-specific prognostic scoring system (CPSS) has been validated in subjects receiving nontransplantation therapy and was included in our study. From 2001 to 2012, 209 adult subjects who received HCT for CMML were reported to the Center for International Blood and Marrow Transplant Research. The median age at transplantation was 57 years (range, 23 to 74). Median follow-up was 51 months (range, 3 to 122). On multivariate analyses, CPSS scores, Karnofsky performance status (KPS), and graft source were significant predictors of survival (P = .004, P = .01, P = .01, respectively). Higher CPSS scores were not associated with disease-free survival, relapse, or transplantation-related mortality. In a restricted analysis of subjects with relapse after HCT, those with intermediate-2/high risk had a nearly 2-fold increased risk of death after relapse compared to those with low/intermediate-1 CPSS scores. Respective 1-year, 3-year, and 5-year survival rates for low/intermediate-1 risk subjects were 61% (95% confidence interval [CI], 52% to 72%), 48% (95% CI, 37% to 59%), and 44% (95% CI, 33% to 55%), and for intermediate-2/high risk subjects were 38% (95% CI, 28% to 49%), 32% (95% CI, 21% to 42%), and 19% (95% CI, 8% to 29%). We conclude that higher CPSS score at time of transplantation, lower KPS, and a bone marrow graft are associated with inferior survival after HCT. Further investigation of CMML disease-related biology may provide insights into other risk factors predictive of post-transplantation outcomes.
DOI: 10.1016/j.bbmt.2017.01.078
PubMed: 28115276
Affiliations:
- Arabie saoudite, Australie, Canada, France, Israël, Japon, Royaume-Uni, Suède, États-Unis
- Alabama, Arizona, Auvergne-Rhône-Alpes, Caroline du Nord, East Middle Sweden, Floride, Massachusetts, Minnesota, Ohio, Oregon, Rhône-Alpes, Région de Kantō, Svealand, Tennessee, Texas, Virginie, Washington (État), Wisconsin, État de New York
- Grenoble, Tokyo, Uppsala
- Université d'Uppsala
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Electronic address: liuh@ccf.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation wicri:level="2"><nlm:affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Oncology, University of Miami Sylvester Cancer Center, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Hematology and Oncology, University of Miami Sylvester Cancer Center, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rizzieri, David" sort="Rizzieri, David" uniqKey="Rizzieri D" first="David" last="Rizzieri">David Rizzieri</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R" last="Grunwald">Michael R. Grunwald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name><affiliation wicri:level="4"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Bajel, Ashish" sort="Bajel, Ashish" uniqKey="Bajel A" first="Ashish" last="Bajel">Ashish Bajel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Bone Marrow Transplant, Royal Melbourne Hospital, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology and Bone Marrow Transplant, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name><affiliation wicri:level="1"><nlm:affiliation>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Andrew" sort="Daly, Andrew" uniqKey="Daly A" first="Andrew" last="Daly">Andrew Daly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Tom Baker Cancer Centre, Calgary, Canada; Department of Oncology, Tom Baker Cancer Centre, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Tom Baker Cancer Centre, Calgary, Canada; Department of Oncology, Tom Baker Cancer Centre, Calgary</wicri:regionArea><wicri:noRegion>Calgary</wicri:noRegion></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Majhail, Navneet" sort="Majhail, Navneet" uniqKey="Majhail N" first="Navneet" last="Majhail">Navneet Majhail</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation wicri:level="1"><nlm:affiliation>Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gerds, Aaron" sort="Gerds, Aaron" uniqKey="Gerds A" first="Aaron" last="Gerds">Aaron Gerds</name><affiliation wicri:level="2"><nlm:affiliation>Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Malone, Adriana" sort="Malone, Adriana" uniqKey="Malone A" first="Adriana" last="Malone">Adriana Malone</name><affiliation wicri:level="2"><nlm:affiliation>Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name><affiliation wicri:level="2"><nlm:affiliation>Leukemia Service, Department of Medicine, Memorial Sloan, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan, New York</wicri:cityArea></affiliation></author><author><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program and Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Blood and Marrow Transplantation Program and Columbia Center for Translational Immunology, Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Gergis, Usama" sort="Gergis, Usama" uniqKey="Gergis U" first="Usama" last="Gergis">Usama Gergis</name><affiliation wicri:level="2"><nlm:affiliation>Hematologic Malignancies & Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Hematologic Malignancies & Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Savoie, Mary Lynn" sort="Savoie, Mary Lynn" uniqKey="Savoie M" first="Mary Lynn" last="Savoie">Mary Lynn Savoie</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology and Hematologic Malignancies, Tom Baker Cancer Centre, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology and Hematologic Malignancies, Tom Baker Cancer Centre, Calgary, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R" last="Litzow">Mark R. Litzow</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Transplant Center, Mayo Clinic Rochester, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology and Transplant Center, Mayo Clinic Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Kindwall Keller, Tamila" sort="Kindwall Keller, Tamila" uniqKey="Kindwall Keller T" first="Tamila" last="Kindwall-Keller">Tamila Kindwall-Keller</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Gorgun" last="Akpek">Gorgun Akpek</name><affiliation wicri:level="2"><nlm:affiliation>Stem Cell Transplantation and Cellular Therapy Program, Banner MD Anderson Cancer Center, Gilbert, Arizona.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Stem Cell Transplantation and Cellular Therapy Program, Banner MD Anderson Cancer Center, Gilbert</wicri:cityArea></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Hematology, Shaare Zedek Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name><affiliation wicri:level="2"><nlm:affiliation>Our Lady of Mercy Medical Center, Bronx, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Our Lady of Mercy Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W" last="Hsu">Jack W. Hsu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Hematology and Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kalaycio, Matt" sort="Kalaycio, Matt" uniqKey="Kalaycio M" first="Matt" last="Kalaycio">Matt Kalaycio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Maziarz, Richard" sort="Maziarz, Richard" uniqKey="Maziarz R" first="Richard" last="Maziarz">Richard Maziarz</name><affiliation wicri:level="2"><nlm:affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><affiliation wicri:level="2"><nlm:affiliation>Department of Stem Cell Transplantation, MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Stem Cell Transplantation, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Alyea, Edwin" sort="Alyea, Edwin" uniqKey="Alyea E" first="Edwin" last="Alyea">Edwin Alyea</name><affiliation wicri:level="2"><nlm:affiliation>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28115276</idno><idno type="pmid">28115276</idno><idno type="doi">10.1016/j.bbmt.2017.01.078</idno><idno type="wicri:Area/PubMed/Corpus">000C53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C53</idno><idno type="wicri:Area/PubMed/Curation">000C50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C50</idno><idno type="wicri:Area/PubMed/Checkpoint">000C50</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C50</idno><idno type="wicri:Area/Ncbi/Merge">004206</idno><idno type="wicri:Area/Ncbi/Curation">004206</idno><idno type="wicri:Area/Ncbi/Checkpoint">004206</idno><idno type="wicri:Area/Main/Merge">001205</idno><idno type="wicri:Area/Main/Curation">001210</idno><idno type="wicri:Area/Main/Exploration">001210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia.</title><author><name sortKey="Liu, Hien Duong" sort="Liu, Hien Duong" uniqKey="Liu H" first="Hien Duong" last="Liu">Hien Duong Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio. Electronic address: liuh@ccf.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation wicri:level="2"><nlm:affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Oncology, University of Miami Sylvester Cancer Center, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Hematology and Oncology, University of Miami Sylvester Cancer Center, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rizzieri, David" sort="Rizzieri, David" uniqKey="Rizzieri D" first="David" last="Rizzieri">David Rizzieri</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R" last="Grunwald">Michael R. Grunwald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name><affiliation wicri:level="4"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Bajel, Ashish" sort="Bajel, Ashish" uniqKey="Bajel A" first="Ashish" last="Bajel">Ashish Bajel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology and Bone Marrow Transplant, Royal Melbourne Hospital, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology and Bone Marrow Transplant, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name><affiliation wicri:level="1"><nlm:affiliation>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Andrew" sort="Daly, Andrew" uniqKey="Daly A" first="Andrew" last="Daly">Andrew Daly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Tom Baker Cancer Centre, Calgary, Canada; Department of Oncology, Tom Baker Cancer Centre, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Tom Baker Cancer Centre, Calgary, Canada; Department of Oncology, Tom Baker Cancer Centre, Calgary</wicri:regionArea><wicri:noRegion>Calgary</wicri:noRegion></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Majhail, Navneet" sort="Majhail, Navneet" uniqKey="Majhail N" first="Navneet" last="Majhail">Navneet Majhail</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation wicri:level="1"><nlm:affiliation>Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gerds, Aaron" sort="Gerds, Aaron" uniqKey="Gerds A" first="Aaron" last="Gerds">Aaron Gerds</name><affiliation wicri:level="2"><nlm:affiliation>Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Malone, Adriana" sort="Malone, Adriana" uniqKey="Malone A" first="Adriana" last="Malone">Adriana Malone</name><affiliation wicri:level="2"><nlm:affiliation>Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name><affiliation wicri:level="2"><nlm:affiliation>Leukemia Service, Department of Medicine, Memorial Sloan, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan, New York</wicri:cityArea></affiliation></author><author><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program and Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Blood and Marrow Transplantation Program and Columbia Center for Translational Immunology, Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Gergis, Usama" sort="Gergis, Usama" uniqKey="Gergis U" first="Usama" last="Gergis">Usama Gergis</name><affiliation wicri:level="2"><nlm:affiliation>Hematologic Malignancies & Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Hematologic Malignancies & Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Savoie, Mary Lynn" sort="Savoie, Mary Lynn" uniqKey="Savoie M" first="Mary Lynn" last="Savoie">Mary Lynn Savoie</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology and Hematologic Malignancies, Tom Baker Cancer Centre, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology and Hematologic Malignancies, Tom Baker Cancer Centre, Calgary, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R" last="Litzow">Mark R. Litzow</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Transplant Center, Mayo Clinic Rochester, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology and Transplant Center, Mayo Clinic Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Kindwall Keller, Tamila" sort="Kindwall Keller, Tamila" uniqKey="Kindwall Keller T" first="Tamila" last="Kindwall-Keller">Tamila Kindwall-Keller</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Gorgun" last="Akpek">Gorgun Akpek</name><affiliation wicri:level="2"><nlm:affiliation>Stem Cell Transplantation and Cellular Therapy Program, Banner MD Anderson Cancer Center, Gilbert, Arizona.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Stem Cell Transplantation and Cellular Therapy Program, Banner MD Anderson Cancer Center, Gilbert</wicri:cityArea></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Hematology, Shaare Zedek Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name><affiliation wicri:level="2"><nlm:affiliation>Our Lady of Mercy Medical Center, Bronx, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Our Lady of Mercy Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W" last="Hsu">Jack W. Hsu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Hematology and Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kalaycio, Matt" sort="Kalaycio, Matt" uniqKey="Kalaycio M" first="Matt" last="Kalaycio">Matt Kalaycio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Maziarz, Richard" sort="Maziarz, Richard" uniqKey="Maziarz R" first="Richard" last="Maziarz">Richard Maziarz</name><affiliation wicri:level="2"><nlm:affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><affiliation wicri:level="2"><nlm:affiliation>Department of Stem Cell Transplantation, MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Stem Cell Transplantation, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Alyea, Edwin" sort="Alyea, Edwin" uniqKey="Alyea E" first="Edwin" last="Alyea">Edwin Alyea</name><affiliation wicri:level="2"><nlm:affiliation>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Allogeneic hematopoietic cell transplantation (HCT) is potentially curative for patients with chronic myelomonocytic leukemia (CMML); however, few data exist regarding prognostic factors and transplantation outcomes. We performed this retrospective study to identify prognostic factors for post-transplantation outcomes. The CMML-specific prognostic scoring system (CPSS) has been validated in subjects receiving nontransplantation therapy and was included in our study. From 2001 to 2012, 209 adult subjects who received HCT for CMML were reported to the Center for International Blood and Marrow Transplant Research. The median age at transplantation was 57 years (range, 23 to 74). Median follow-up was 51 months (range, 3 to 122). On multivariate analyses, CPSS scores, Karnofsky performance status (KPS), and graft source were significant predictors of survival (P = .004, P = .01, P = .01, respectively). Higher CPSS scores were not associated with disease-free survival, relapse, or transplantation-related mortality. In a restricted analysis of subjects with relapse after HCT, those with intermediate-2/high risk had a nearly 2-fold increased risk of death after relapse compared to those with low/intermediate-1 CPSS scores. Respective 1-year, 3-year, and 5-year survival rates for low/intermediate-1 risk subjects were 61% (95% confidence interval [CI], 52% to 72%), 48% (95% CI, 37% to 59%), and 44% (95% CI, 33% to 55%), and for intermediate-2/high risk subjects were 38% (95% CI, 28% to 49%), 32% (95% CI, 21% to 42%), and 19% (95% CI, 8% to 29%). We conclude that higher CPSS score at time of transplantation, lower KPS, and a bone marrow graft are associated with inferior survival after HCT. Further investigation of CMML disease-related biology may provide insights into other risk factors predictive of post-transplantation outcomes.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Australie</li><li>Canada</li><li>France</li><li>Israël</li><li>Japon</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Alabama</li><li>Arizona</li><li>Auvergne-Rhône-Alpes</li><li>Caroline du Nord</li><li>East Middle Sweden</li><li>Floride</li><li>Massachusetts</li><li>Minnesota</li><li>Ohio</li><li>Oregon</li><li>Rhône-Alpes</li><li>Région de Kantō</li><li>Svealand</li><li>Tennessee</li><li>Texas</li><li>Virginie</li><li>Washington (État)</li><li>Wisconsin</li><li>État de New York</li></region><settlement><li>Grenoble</li><li>Tokyo</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Liu, Hien Duong" sort="Liu, Hien Duong" uniqKey="Liu H" first="Hien Duong" last="Liu">Hien Duong Liu</name></region><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Gorgun" last="Akpek">Gorgun Akpek</name><name sortKey="Alyea, Edwin" sort="Alyea, Edwin" uniqKey="Alyea E" first="Edwin" last="Alyea">Edwin Alyea</name><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><name sortKey="Gerds, Aaron" sort="Gerds, Aaron" uniqKey="Gerds A" first="Aaron" last="Gerds">Aaron Gerds</name><name sortKey="Gergis, Usama" sort="Gergis, Usama" uniqKey="Gergis U" first="Usama" last="Gergis">Usama Gergis</name><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R" last="Grunwald">Michael R. Grunwald</name><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W" last="Hsu">Jack W. Hsu</name><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><name sortKey="Kalaycio, Matt" sort="Kalaycio, Matt" uniqKey="Kalaycio M" first="Matt" last="Kalaycio">Matt Kalaycio</name><name sortKey="Kindwall Keller, Tamila" sort="Kindwall Keller, Tamila" uniqKey="Kindwall Keller T" first="Tamila" last="Kindwall-Keller">Tamila Kindwall-Keller</name><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R" last="Litzow">Mark R. Litzow</name><name sortKey="Majhail, Navneet" sort="Majhail, Navneet" uniqKey="Majhail N" first="Navneet" last="Majhail">Navneet Majhail</name><name sortKey="Malone, Adriana" sort="Malone, Adriana" uniqKey="Malone A" first="Adriana" last="Malone">Adriana Malone</name><name sortKey="Maziarz, Richard" sort="Maziarz, Richard" uniqKey="Maziarz R" first="Richard" last="Maziarz">Richard Maziarz</name><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name><name sortKey="Rizzieri, David" sort="Rizzieri, David" uniqKey="Rizzieri D" first="David" last="Rizzieri">David Rizzieri</name><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name></country><country name="Canada"><noRegion><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name></noRegion><name sortKey="Bredeson, Christopher" sort="Bredeson, Christopher" uniqKey="Bredeson C" first="Christopher" last="Bredeson">Christopher Bredeson</name><name sortKey="Daly, Andrew" sort="Daly, Andrew" uniqKey="Daly A" first="Andrew" last="Daly">Andrew Daly</name><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><name sortKey="Savoie, Mary Lynn" sort="Savoie, Mary Lynn" uniqKey="Savoie M" first="Mary Lynn" last="Savoie">Mary Lynn Savoie</name></country><country name="Suède"><region name="Svealand"><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name></region></country><country name="Australie"><noRegion><name sortKey="Bajel, Ashish" sort="Bajel, Ashish" uniqKey="Bajel A" first="Ashish" last="Bajel">Ashish Bajel</name></noRegion></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name></region></country><country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M" last="Rowe">Jacob M. Rowe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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